Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2066642 | 0.80 | PDE4A (0.35) | KLKB1RAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL2066942 | 0.77 | CDK2 (0.35) | KDM4ETP53RAB9AALDH1A1HPGD | |
| SCHEMBL9934111 | 0.77 | ERCC5 (0.35) | KLKB1ERCC5PDE4APDE4BPDE4D | |
| SCHEMBL876570 | 0.77 | KLKB1 (0.33) | KLKB1RAB9ANPC1SMN1; SMN2ERCC5 | |
| SCHEMBL30224182 | 0.76 | KDM4E (0.36) | KDM4ERAB9AALDH1A1HPGDNPC1 | |
| SCHEMBL21167757 | 0.76 | DYRK1A (0.41) | KDM4ETP53CYP2A6CYP3A4ADRB2 | |
| SCHEMBL9968611 | 0.76 | PDE4A (0.33) | KLKB1ERCC5PDE4ARBP4 | |
| SCHEMBL9569919 | 0.74 | ERCC5 (0.34) | KLKB1ALDH1A1SMN1; SMN2ERCC5PDE4A | |
| SCHEMBL7969411 | 0.74 | KLKB1 (0.34) | KLKB1ERCC5PDE4ARBP4 | |
| SCHEMBL5148627 | 0.73 | POLB (0.35) | KDM4EKLKB1ALDH1A1HPGDERCC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019178129-A1 | SUBSTITUTED IMIDAZOPYRIDINES AS INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2019-09-19 | — | — | WO | disclosed |