Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 14/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170344 | 0.91 | IL1B (0.37) | IL1BTNFMAPTNPC1RAB9A | |
| SCHEMBL21170492 | 0.83 | IL1B (0.34) | IL1BTNFMAPTUSP2 | |
| SCHEMBL21170213 | 0.82 | IL1B (0.37) | IL1BTNFNPC1RAB9ANLRP3 | |
| SCHEMBL21170234 | 0.81 | IL1B (0.35) | IL1BTNFMAPTNPC1RAB9A | |
| SCHEMBL21170415 | 0.80 | IL1B (0.36) | IL1BTNFNPC1RAB9A | |
| SCHEMBL21170260 | 0.79 | IL1B (0.33) | IL1BTNF | |
| SCHEMBL21170421 | 0.79 | IL1B (0.33) | IL1BTNF | |
| SCHEMBL21170341 | 0.78 | IL1B (0.39) | IL1BTNFMAPTNPC1RAB9A | |
| SCHEMBL21170272 | 0.77 | IL1B (0.39) | IL1BTNFMAPTNPC1RAB9A | |
| SCHEMBL21170299 | 0.76 | NPC1 (0.47) | IL1BTNFMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |