Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | IL1B | P01584 | 8/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170358 | 0.84 | PSEN1 (0.39) | SLC6A2SLC6A4SLC6A3PSEN1PSEN2 | |
| SCHEMBL21170134 | 0.84 | PSEN1 (0.37) | SLC6A2SLC6A4SLC6A3PSEN1PSEN2 | |
| SCHEMBL21170238 | 0.81 | PSEN1 (0.37) | SLC6A2SLC6A4SLC6A3PSEN1PSEN2 | |
| SCHEMBL12288231 | 0.80 | NPC1 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21170112 | 0.79 | PSEN1 (0.35) | SLC6A2SLC6A4SLC6A3PSEN1PSEN2 | |
| SCHEMBL21170473 | 0.79 | PSEN1 (0.35) | SLC6A2SLC6A4SLC6A3PSEN1PSEN2 | |
| SCHEMBL21170322 | 0.78 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3PSEN1PSEN2 | |
| SCHEMBL12287815 | 0.76 | FGFR1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12288241 | 0.76 | NPC1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21170278 | 0.76 | IL1B (0.33) | NPC1RAB9AMEN1KMT2AIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |