Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 7/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.32 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170213 | 0.91 | IL1B (0.37) | IL1BFPR2SCN9APSEN1PSEN2 | |
| SCHEMBL21170253 | 0.89 | IL1B (0.36) | IL1BFPR2SCN9APSEN1PSEN2 | |
| SCHEMBL21170493 | 0.89 | IL1B (0.37) | IL1BFPR2SCN9APSEN1PSEN2 | |
| SCHEMBL21170265 | 0.88 | IL1B (0.36) | IL1BFPR2SCN9APSEN1PSEN2 | |
| SCHEMBL21170489 | 0.87 | IL1B (0.36) | IL1BFPR2SCN9APSEN1PSEN2 | |
| SCHEMBL21170503 | 0.86 | IL1B (0.36) | IL1BPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21170119 | 0.85 | IL1B (0.35) | IL1BPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21170248 | 0.85 | HPGD (0.34) | IL1BFPR2SCN9APSEN1PSEN2 | |
| SCHEMBL18470528 | 0.84 | IL1B (0.34) | IL1BFPR2SCN9APSEN1PSEN2 | |
| SCHEMBL21170344 | 0.82 | IL1B (0.37) | IL1BNPC1RAB9ATNFMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |