SCHEMBL21170633

SCHEMBL21170633

CCNc1c(-c2c(F)cc(F)cc2F)c(Cl)nc2nccnc12

nearest known ligand 0.31

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PRKD3 O94806 1/20 0.31
TGFBR1 P36897 1/20 0.31
PRKD1 Q15139 1/20 0.31
PRKD2 Q9BZL6 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13906826 0.88 TLR8 (0.34)
SCHEMBL13906841 0.86 ESR1 (0.35)
SCHEMBL13906839 0.83 MAPK14 (0.32)
SCHEMBL4164674 0.82 MAPK14 (0.32) PRKD3TGFBR1PRKD1PRKD2
SCHEMBL13906827 0.79 KMT2A (0.32) PRKD3TGFBR1PRKD1PRKD2
SCHEMBL13906848 0.78 CDC7 (0.34)
SCHEMBL4151460 0.78 PRKD3 (0.33) PRKD3TGFBR1PRKD1PRKD2
SCHEMBL13906831 0.77 KMT2A (0.38)
SCHEMBL13906829 0.77 KMT2A (0.35)
SCHEMBL13906865 0.76 TLR8 (0.39)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2903436-B1 HETEROCYCLIC COMPOUNDS AND THEIR USE FOR THE TREATMENT OF NEURODEGENERATIVE TAUOPATHIES UNIV PENNSYLVANIA (US) 2019-07-17 EP disclosed