Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 5/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.39 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.39 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.39 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24347198 | 0.82 | HPGD (0.55) | HSD17B3NOTUMKDM4EMAPTALDH1A1 | |
| SCHEMBL21172600 | 0.82 | NOTUM (0.60) | HSD17B3NOTUMMEN1KMT2AALDH1A1 | |
| SCHEMBL21172928 | 0.82 | HPGD (0.55) | HSD17B3NOTUMKDM4EMAPTALDH1A1 | |
| SCHEMBL21172572 | 0.82 | NOTUM (0.60) | HSD17B3NOTUMMEN1KMT2AALDH1A1 | |
| SCHEMBL21172588 | 0.81 | KDM4E (0.47) | HSD17B3NOTUMKDM4EGAAMAPT | |
| SCHEMBL21172491 | 0.80 | ALDH1A1 (0.42) | NOTUMKDM4EMEN1GAAMAPT | |
| SCHEMBL21172664 | 0.80 | HSD17B3 (0.52) | HSD17B3NOTUMKDM4EMAPTALDH1A1 | |
| SCHEMBL24347806 | 0.80 | HSD17B3 (0.52) | HSD17B3NOTUMKDM4EMAPTALDH1A1 | |
| SCHEMBL21172770 | 0.80 | NOTUM (0.62) | HSD17B3NOTUMALDH1A1TRIM24 | |
| SCHEMBL21172573 | 0.80 | ALDH1A1 (0.42) | NOTUMKDM4EMEN1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511323-A1 | 2,3-DISUBSTITUTED 1-ACYL-4-AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS | GlaxoSmithKline Intellectual Property (No.2) Limited (GB) | 2019-07-17 | — | — | EP | disclosed |