Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 5/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.36 |
| ▸ | CCL2 | P13500 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21172653 | 0.90 | HPGD (0.41) | MAPTHPGDHDAC8SMYD3 | |
| SCHEMBL24347808 | 0.90 | HPGD (0.41) | MAPTHPGDHDAC8SMYD3 | |
| SCHEMBL21173003 | 0.88 | OPRM1 (0.41) | OPRM1OPRD1MAPTHPGDALOX15 | |
| SCHEMBL21172994 | 0.88 | HTT (0.51) | OPRM1MAPTHPGDALOX15 | |
| SCHEMBL21172638 | 0.88 | HTT (0.51) | OPRM1MAPTHPGDALOX15 | |
| SCHEMBL24347629 | 0.86 | PRKD1 (0.38) | MAPTHPGDHDAC8SMYD3 | |
| SCHEMBL21172586 | 0.85 | TDP1 (0.43) | MAPTHPGDALOX15 | |
| SCHEMBL21172982 | 0.85 | TDP1 (0.43) | MAPTHPGDALOX15 | |
| SCHEMBL21172656 | 0.84 | KDM4E (0.46) | OPRM1OPRD1MAPTHPGDHDAC8 | |
| SCHEMBL21172935 | 0.83 | POLB (0.56) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511323-A1 | 2,3-DISUBSTITUTED 1-ACYL-4-AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS | GlaxoSmithKline Intellectual Property (No.2) Limited (GB) | 2019-07-17 | — | — | EP | disclosed |