Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 6/20 | 0.46 |
| ▸ | CCL2 | P13500 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | PKLR | P30613 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21172697 | 1.00 | BRD4 (0.46) | BRD4CCL2MAPTHPGDTNF | |
| SCHEMBL25008751 | 0.88 | POLB (0.45) | MAPTHPGDRAB9ASMYD3 | |
| SCHEMBL21172627 | 0.88 | POLB (0.45) | MAPTHPGDRAB9ASMYD3 | |
| SCHEMBL21173210 | 0.87 | SMN1; SMN2 (0.38) | BRD4MAPTHPGDTNFRAB9A | |
| SCHEMBL24348098 | 0.87 | SMN1; SMN2 (0.38) | BRD4MAPTHPGDTNFRAB9A | |
| SCHEMBL25008800 | 0.86 | HTT (0.52) | MAPTHPGDRAB9AALOX15GAA | |
| SCHEMBL21172528 | 0.86 | MAPT (0.41) | BRD4MAPTHPGDTNFRAB9A | |
| SCHEMBL21173003 | 0.85 | OPRM1 (0.41) | BRD4MAPTHPGDALOX15HTR7 | |
| SCHEMBL25008791 | 0.84 | SMN1; SMN2 (0.39) | BRD4CCL2MAPTTNFRAB9A | |
| SCHEMBL24347632 | 0.84 | POLB (0.53) | MAPTHPGDALOX15HTR7GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511323-B1 | 2,3-DISUBSTITUTED 1-ACYL-4-AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2022-03-02 | — | — | EP | disclosed |
| EP-3511323-A1 | 2,3-DISUBSTITUTED 1-ACYL-4-AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS | GlaxoSmithKline Intellectual Property (No.2) Limited (GB) | 2019-07-17 | — | — | EP | disclosed |