Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 5/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.47 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | BRD1 | O95696 | 4/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 4/20 | 0.42 |
| ▸ | BRPF3 | Q9ULD4 | 3/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2122228 | 0.86 | ACLY (0.48) | ACLYHSD11B1PTGES2RXFP1DRD2 | |
| SCHEMBL2122365 | 0.86 | MAPT (0.43) | ACLYHSD11B1RXFP1MAPT | |
| SCHEMBL2119785 | 0.80 | ACLY (0.59) | ACLYHSD11B1PTGES2DRD2HTR2A | |
| SCHEMBL2118235 | 0.79 | MAPT (0.41) | DRD2HTR2AHTR2CDRD3HTR6 | |
| SCHEMBL2117688 | 0.78 | ACLY (0.51) | ACLYHSD11B1PTGES2RXFP1DRD2 | |
| SCHEMBL2120254 | 0.78 | ACLY (0.51) | ACLYHSD11B1PTGES2RXFP1 | |
| SCHEMBL3792512 | 0.76 | TRIM24 (0.57) | MAPT | |
| SCHEMBL2120461 | 0.76 | CYP2C9 (0.50) | MAPT | |
| SCHEMBL2119953 | 0.76 | ACLY (0.47) | ACLYHSD11B1PTGES2 | |
| SCHEMBL2119300 | 0.76 | ACLY (0.54) | ACLYHSD11B1PTGES2BRD1BRPF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095012-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE | ELARA PHARMACEUTICALS GMBH (DE) | 2012-04-19 | — | — | US | disclosed |
| EP-2382190-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS-INHIBITORS | European Molecular Biology Laboratory (EMBL) (DE) | 2011-11-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095012-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE | HIF1A, HIF1AN, EGLN3 | ACLY 1578/4885HSD11B1 3376/4885PTGES2 566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.