Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21173306 | 0.82 | PREP (0.39) | PREP | |
| SCHEMBL15934593 | 0.74 | PREP (0.61) | PREPCTSLMEN1ALDH1A1KMT2A | |
| SCHEMBL2097353 | 0.74 | PREP (0.61) | PREPCTSLMEN1ALDH1A1KMT2A | |
| SCHEMBL6621402 | 0.74 | PREP (0.61) | PREPCTSLMEN1ALDH1A1KMT2A | |
| SCHEMBL6620964 | 0.74 | PREP (0.61) | PREPCTSLMEN1ALDH1A1KMT2A | |
| SCHEMBL15934580 | 0.74 | PREP (0.61) | PREPCTSLMEN1ALDH1A1KMT2A | |
| SCHEMBL17862217 | 0.74 | PREP (0.61) | PREPCTSLMEN1ALDH1A1KMT2A | |
| SCHEMBL12294933 | 0.74 | PREP (0.61) | PREPCTSLMEN1ALDH1A1KMT2A | |
| SCHEMBL14583166 | 0.74 | PREP (0.37) | PREP | |
| SCHEMBL4736905 | 0.72 | MAPT (0.36) | KCNH2MEN1ALDH1A1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191487-B1 | SPIROCYCLIC INHIBITORS OF CATHEPSIN C | BOEHRINGER INGELHEIM INT (DE) | 2019-08-07 | — | — | EP | disclosed |
| EP-3511331-A1 | SPIROCYCLIC INHIBITORS OF CATHEPSIN C | Boehringer Ingelheim International GmbH (DE) | 2019-07-17 | — | — | EP | disclosed |