Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14583166 | 0.91 | PREP (0.37) | PREPCHRM2CHRM1CHRM3ELANE | |
| SCHEMBL18828778 | 0.83 | PREP (0.38) | PREPCHRM2CHRM1CHRM3TDP1 | |
| SCHEMBL21173305 | 0.82 | PREP (0.36) | PREP | |
| SCHEMBL26206910 | 0.76 | TDP1 (0.38) | PREPLMNACYP2C9CHRM2CHRM1 | |
| SCHEMBL28153160 | 0.72 | OGFRL1 (0.38) | PREPLMNACYP2D6CYP2C9CHRM2 | |
| SCHEMBL15430116 | 0.71 | TDP1 (0.46) | PREPLMNACYP2D6CYP2C9HSD17B10 | |
| SCHEMBL19883625 | 0.71 | TDP1 (0.46) | PREPLMNACYP2D6CYP2C9HSD17B10 | |
| SCHEMBL18829248 | 0.71 | TDP1 (0.46) | PREPLMNACYP2D6CYP2C9HSD17B10 | |
| SCHEMBL16076329 | 0.71 | TDP1 (0.46) | PREPLMNACYP2D6CYP2C9HSD17B10 | |
| SCHEMBL18943176 | 0.71 | TDP1 (0.46) | PREPLMNACYP2D6CYP2C9HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191487-B1 | SPIROCYCLIC INHIBITORS OF CATHEPSIN C | BOEHRINGER INGELHEIM INT (DE) | 2019-08-07 | — | — | EP | disclosed |
| EP-3511331-A1 | SPIROCYCLIC INHIBITORS OF CATHEPSIN C | Boehringer Ingelheim International GmbH (DE) | 2019-07-17 | — | — | EP | disclosed |