Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.63 |
| ▸ | PRKAA1 | Q13131 | 9/20 | 0.55 |
| ▸ | PRKAA2 | P54646 | 8/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.51 |
| ▸ | KIT | P10721 | 3/20 | 0.51 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.48 |
| ▸ | RET | P07949 | 3/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.48 |
| ▸ | FLT3 | P36888 | 3/20 | 0.48 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.48 |
| ▸ | PLK4 | O00444 | 2/20 | 0.48 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.48 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31672503 | 1.00 | KDR (0.63) | KDRPRKAA1PRKAA2LRRK2PDGFRB | |
| SCHEMBL13755189 | 1.00 | KDR (0.63) | KDRPRKAA1PRKAA2LRRK2PDGFRB | |
| SCHEMBL2115628 | 0.93 | KDR (0.55) | KDRPRKAA1PRKAA2LRRK2PDGFRB | |
| SCHEMBL13755190 | 0.93 | KDR (0.55) | KDRPRKAA1PRKAA2LRRK2PDGFRB | |
| SCHEMBL31672397 | 0.88 | KDR (0.62) | KDRPRKAA1PRKAA2LRRK2PDGFRB | |
| SCHEMBL13755180 | 0.88 | KDR (0.62) | KDRPRKAA1PRKAA2LRRK2PDGFRB | |
| SCHEMBL2117421 | 0.88 | KDR (0.62) | KDRPRKAA1PRKAA2LRRK2PDGFRB | |
| SCHEMBL13755179 | 0.87 | KDR (0.59) | KDRPRKAA1PRKAA2LRRK2PDGFRB | |
| SCHEMBL2114173 | 0.87 | KDR (0.59) | KDRPRKAA1PRKAA2LRRK2PDGFRB | |
| SCHEMBL2114541 | 0.81 | CHEK1 (0.53) | KDRPRKAA1PRKAA2PDGFRBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | NEKTAR THERAPEUTICS (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | PTK2B, ERBB2, FRK | KDR 395/4885PRKAA1 881/4885PRKAA2 917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.