Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.30 |
| ▸ | PTGES | O14684 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211762 | 1.00 | MAPT (0.36) | MAPTEPHX2KDM4EALDH1A1LMNA | |
| SCHEMBL211760 | 1.00 | MAPT (0.36) | MAPTEPHX2KDM4EALDH1A1LMNA | |
| SCHEMBL2725247 | 0.94 | MAPT (0.41) | MAPTKDM4EALDH1A1THRBTP53 | |
| SCHEMBL2727292 | 0.91 | MAPT (0.35) | MAPTEPHX2KDM4EALDH1A1LMNA | |
| SCHEMBL2725253 | 0.90 | KDM4E (0.33) | MAPTKDM4EALDH1A1TP53MAPK1 | |
| SCHEMBL213927 | 0.89 | MAPT (0.36) | MAPTEPHX2KDM4EALDH1A1LMNA | |
| SCHEMBL9607957 | 0.89 | MAPT (0.38) | MAPTEPHX2KDM4EALDH1A1LMNA | |
| SCHEMBL214098 | 0.89 | MAPT (0.38) | MAPTEPHX2KDM4EALDH1A1LMNA | |
| SCHEMBL14733485 | 0.89 | MAPT (0.37) | MAPTEPHX2KDM4EALDH1A1LMNA | |
| SCHEMBL2839609 | 0.89 | MAPT (0.38) | MAPTEPHX2KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |