Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGKA | P23743 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 5/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | TLR2 | O60603 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | NDUFS8 | O00217 | 2/20 | 0.33 |
| ▸ | COXFA4 | O00483 | 2/20 | 0.33 |
| ▸ | NDUFAB1 | O14561 | 2/20 | 0.33 |
| ▸ | NDUFA1 | O15239 | 2/20 | 0.33 |
| ▸ | NDUFS4 | O43181 | 2/20 | 0.33 |
| ▸ | NDUFB5 | O43674 | 2/20 | 0.33 |
| ▸ | NDUFB3 | O43676 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL39389 | 1.00 | DGKA (0.37) | DGKAS1PR1S1PR3S1PR4CNR2 | |
| SCHEMBL29880580 | 1.00 | DGKA (0.37) | DGKAS1PR1S1PR3S1PR4CNR2 | |
| SCHEMBL29413921 | 1.00 | DGKA (0.37) | DGKAS1PR1S1PR3S1PR4CNR2 | |
| SCHEMBL984668 | 0.97 | DGKA (0.34) | DGKAS1PR1S1PR3S1PR4CNR2 | |
| SCHEMBL12679255 | 0.95 | MEN1 (0.35) | ALDH2MAOAMAOBESR1ESR2 | |
| SCHEMBL26025226 | 0.95 | CNR2 (0.37) | DGKAS1PR1S1PR3S1PR4CNR2 | |
| SCHEMBL13525823 | 0.93 | ALDH2 (0.35) | CNR2ALDH2MAOAMAOBTLR2 | |
| SCHEMBL2612432 | 0.93 | KMT2A (0.34) | ALDH2MAOAMAOBESR1ESR2 | |
| SCHEMBL14175644 | 0.92 | ALDH2 (0.34) | CNR2ALDH2MAOAMAOB | |
| SCHEMBL23487143 | 0.92 | CNR2 (0.32) | DGKAS1PR1S1PR3S1PR4CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11739200-B2 | 3-phenyl-3H-1-benzofuran-2-one compounds and compositions comprising the same | MILLIKEN & COMPANY (US) | 2023-08-29 | — | — | US | disclosed |
| CN-111670214-B | 3-phenyl-3H-1-benzofuran-2-one compounds and compositions comprising the same | 美利肯公司 | 2022-08-16 | — | — | CN | disclosed |
| US-20210171747-A1 | 3-PHENYL-3H-1-BENZOFURAN-2-ONE COMPOUNDS AND COMPOSITIONS COMPRISING THE SAME | MILLIKEN & COMPANY | 2021-06-10 | — | — | US | disclosed |
| US-10947370-B2 | 3-phenyl-3H-1-benzofuran-2-one compounds and compositions comprising the same | MILLIKEN & COMPANY (US) | 2021-03-16 | — | — | US | disclosed |
| CN-111670214-A | 3-phenyl-3H-1-benzofuran-2-one compounds and compositions comprising the same | 美利肯公司 | 2020-09-15 | — | — | CN | disclosed |
| US-20190225780-A1 | 3-PHENYL-3H-1-BENZOFURAN-2-ONE COMPOUNDS AND COMPOSITIONS COMPRISING THE SAME | MILLIKEN & COMPANY | 2019-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210171747-A1 | 3-PHENYL-3H-1-BENZOFURAN-2-ONE COMPOUNDS AND COMPOSITIONS COMPRISING THE SAME | PAH, TRPV1, CBR1 | DGKA 3845/4885S1PR1 3550/4885S1PR3 2989/4885 |
| US-10947370-B2 | 3-phenyl-3H-1-benzofuran-2-one compounds and compositions comprising the same | PAH, TRPV1, CBR1 | DGKA 3845/4885S1PR1 3550/4885S1PR3 2989/4885 |
| US-11739200-B2 | 3-phenyl-3H-1-benzofuran-2-one compounds and compositions comprising the same | PAH, TRPV1, CBR1 | DGKA 3845/4885S1PR1 3550/4885S1PR3 2989/4885 |
| US-20190225780-A1 | 3-PHENYL-3H-1-BENZOFURAN-2-ONE COMPOUNDS AND COMPOSITIONS COMPRISING THE SAME | PAH, TRPV1, CBR1 | DGKA 3845/4885S1PR1 3550/4885S1PR3 2989/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.