SCHEMBL21177301

SCHEMBL21177301

Clc1cnc2ccc(Cc3coc(COCc4ccccc4)n3)cc2c1

nearest known ligand 0.40

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
KLKB1 P03952 19/20 0.40
MAP4K1 Q92918 13/20 0.38
PTGER1 P34995 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21179325 0.82 PTGER1 (0.34) PTGER1
SCHEMBL21177523 0.81 KLKB1 (0.46) KLKB1MAP4K1
SCHEMBL21177602 0.75 KLKB1 (0.44) KLKB1MAP4K1
SCHEMBL21177641 0.74 KLKB1 (0.48) KLKB1MAP4K1
SCHEMBL21190100 0.72 KLKB1 (0.36) KLKB1MAP4K1
SCHEMBL21028255 0.70 KLKB1 (0.60) KLKB1MAP4K1PTGER1
SCHEMBL22276469 0.69 KLKB1 (0.48) KLKB1MAP4K1
SCHEMBL21027816 0.69 KLKB1 (0.40) KLKB1MAP4K1
SCHEMBL19780332 0.68 KLKB1 (0.47) KLKB1MAP4K1
SCHEMBL10048357 0.68 RAB9A (0.43) PTGER1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019142053-A2 THERAPEUTIC INHIBITORY COMPOUNDS LIFESCI PHARMACEUTICALS, INC. (BB) 2019-07-25 WO disclosed
WO-2019142053-A2 THERAPEUTIC INHIBITORY COMPOUNDS LIFESCI PHARMACEUTICALS, INC. (BB) 2019-07-25 WO disclosed