Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 6/20 | 0.39 |
| ▸ | CA1 | P00915 | 6/20 | 0.39 |
| ▸ | CA2 | P00918 | 6/20 | 0.39 |
| ▸ | CA7 | P43166 | 6/20 | 0.39 |
| ▸ | CA9 | Q16790 | 6/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 6/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31358932 | 0.80 | CA12 (0.44) | NPSR1CA12CA1CA2CA7 | |
| SCHEMBL21177534 | 0.73 | NPSR1 (0.44) | NPSR1CA12CA1CA2CA7 | |
| SCHEMBL161461 | 0.70 | CA12 (0.44) | NPSR1CA12CA1CA2CA7 | |
| SCHEMBL6518977 | 0.70 | CA12 (0.45) | NPSR1CA12CA1CA2CA7 | |
| SCHEMBL31589851 | 0.69 | NPSR1 (0.43) | NPSR1CA1CA2ALDH1A1MAPT | |
| SCHEMBL30187763 | 0.68 | ALDH1A1 (0.48) | CA12CA1CA2CA7CA9 | |
| SCHEMBL21179361 | 0.68 | ALDH1A1 (0.32) | IRAK4ALDH1A1MEN1KMT2AACHE | |
| SCHEMBL30079550 | 0.68 | ALDH1A1 (0.48) | CA12CA1CA2CA7CA9 | |
| SCHEMBL2942817 | 0.66 | IRAK4 (0.66) | NPSR1CA12CA1CA2CA7 | |
| SCHEMBL27659257 | 0.66 | HCAR2 (0.52) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11685729-B2 | C5a receptor modulators | IDORSIA PHARMACEUTICALS LTD. (CH) | 2023-06-27 | — | — | US | disclosed |
| US-20210122736-A1 | C5A RECEPTOR MODULATORS | IDORSIA PHARMACEUTICALS LTD. (CH) | 2021-04-29 | — | — | US | disclosed |
| EP-3740477-A1 | C5A RECEPTOR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2020-11-25 | — | — | EP | disclosed |
| CN-111683937-A | C5a receptor modulators | 爱杜西亚药品有限公司 | 2020-09-18 | — | — | CN | disclosed |
| WO-2019141808-A1 | C5A RECEPTOR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2019-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210122736-A1 | C5A RECEPTOR MODULATORS | C5AR1, C3AR1, C5AR2 | NPSR1 105/4885CA12 4471/4885CA1 4623/4885 |
| US-11685729-B2 | C5a receptor modulators | C5AR1, C3AR1, C5AR2 | NPSR1 105/4885CA12 4471/4885CA1 4623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.