Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.34 |
| ▸ | EED | O75530 | 1/20 | 0.34 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.34 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.34 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.34 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7223858 | 0.71 | HPGD (0.68) | LMNAHPGDCYP1A2TSHRKDM4E | |
| SCHEMBL21177349 | 0.71 | HPGD (0.46) | HPGDCYP1A2TSHRKDM4EALDH1A1 | |
| SCHEMBL21177406 | 0.69 | CDK1 (0.49) | HPGDCYP1A2GPR35TSHRKDM4E | |
| SCHEMBL2355505 | 0.68 | AKR1C3 (0.44) | HPGDGPR35TSHRKDM4EALDH1A1 | |
| SCHEMBL11869160 | 0.68 | KDR (0.46) | LMNAHPGDCYP1A2KDM4EALDH1A1 | |
| SCHEMBL29101565 | 0.67 | KDM4E (0.39) | LMNAHPGDCYP1A2KDM4EALDH1A1 | |
| SCHEMBL100826 | 0.66 | CNR1 (0.42) | HPGDCYP1A2KDM4EALDH1A1NPC1 | |
| SCHEMBL23243601 | 0.66 | HPGD (0.47) | LMNAHPGDCYP1A2TSHRKDM4E | |
| SCHEMBL13753904 | 0.66 | KDM4E (0.62) | LMNAHPGDCYP1A2KDM4EALDH1A1 | |
| SCHEMBL17434217 | 0.66 | HDAC1 (0.41) | LMNAHPGDCYP1A2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3740489-A1 | PI4KIIIBETA INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2020-11-25 | — | — | EP | disclosed |
| WO-2019141694-A1 | PI4KIIIBETA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-07-25 | — | — | WO | disclosed |