SCHEMBL21178173

SCHEMBL21178173

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nearest known ligand 0.41

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 3/20 0.41
KEAP1 Q14145 1/20 0.35
NFE2L2 Q16236 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9238752 1.00 HCAR2 (0.41) HCAR2KEAP1NFE2L2
SCHEMBL21178373 1.00 HCAR2 (0.41) HCAR2KEAP1NFE2L2
SCHEMBL27713816 0.91 HCAR2 (0.56) HCAR2
SCHEMBL1255839 0.91 HCAR2 (0.56) HCAR2
SCHEMBL9242314 0.89 HCAR2 (0.56) HCAR2KEAP1NFE2L2
SCHEMBL9241506 0.89 HCAR2 (0.59) HCAR2KEAP1NFE2L2
SCHEMBL9243024 0.84 HCAR2 (0.38) HCAR2KEAP1NFE2L2
SCHEMBL9576162 0.83 HCAR2 (0.35) HCAR2KEAP1NFE2L2
SCHEMBL9240699 0.83 HCAR2 (0.53) HCAR2
SCHEMBL27880777 0.82

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019143560-A9 METHODS FOR PROMOTING MITOCHONDRIAL BIOGENESIS IN NEURAL CELLS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-09-12 WO claimed
WO-2019143560-A1 METHODS FOR PROMOTING MITOCHONDRIAL BIOGENESIS IN NEURAL CELLS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-07-25 WO claimed
WO-2019143560-A9 METHODS FOR PROMOTING MITOCHONDRIAL BIOGENESIS IN NEURAL CELLS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-09-12 WO disclosed
WO-2019143560-A1 METHODS FOR PROMOTING MITOCHONDRIAL BIOGENESIS IN NEURAL CELLS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-07-25 WO disclosed