SCHEMBL9238752

SCHEMBL9238752

O=C(C=CC(=O)OC(F)C(F)F)OC(F)C(F)F

nearest known ligand 0.41

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 3/20 0.41
KEAP1 Q14145 1/20 0.35
NFE2L2 Q16236 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21178173 1.00 HCAR2 (0.41) HCAR2KEAP1NFE2L2
SCHEMBL21178373 1.00 HCAR2 (0.41) HCAR2KEAP1NFE2L2
SCHEMBL27713816 0.91 HCAR2 (0.56) HCAR2
SCHEMBL1255839 0.91 HCAR2 (0.56) HCAR2
SCHEMBL9242314 0.89 HCAR2 (0.56) HCAR2KEAP1NFE2L2
SCHEMBL9241506 0.89 HCAR2 (0.59) HCAR2KEAP1NFE2L2
SCHEMBL9243024 0.84 HCAR2 (0.38) HCAR2KEAP1NFE2L2
SCHEMBL9576162 0.83 HCAR2 (0.35) HCAR2KEAP1NFE2L2
SCHEMBL9240699 0.83 HCAR2 (0.53) HCAR2
SCHEMBL27880777 0.82

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0434362-B1 Graft copolymer, solution containing the graft copolymer, and method of treating contact lens with the solution TOMEI SANGYO KK (JP) 1995-03-22 EP disclosed
EP-0433046-B1 Polymer-type polymerization initiator TOMEI SANGYO KK (JP) 1994-08-10 EP disclosed
EP-0219884-B1 HARD CONTACT LENS MATERIAL Tomei Sangyo Kabushiki Kaisha (JP) 1993-09-29 EP disclosed
US-5206298-A GRAFT COPOLYMER, SOLUTION CONTAINING THE GRAFT COPOLYMER FOR TREATING CONTACT LENS, AND METHOD OF TREATING CONTACT LENS WITH THE SOLUTION AND MAKING HYDROPHILIC LENS SURFACE TOMEI SANGYO KABUSHIKI KAISHA (JP) 1993-04-27 US disclosed
US-5142009-A Crosslinked blend of fumaric acid diesters TOMEI SANGYO KABUSHIKI KAISHA (JP) 1992-08-25 US disclosed
US-5134213-A N-Vinyllactam-Monoperoxyfumarate Terpolymer TOMEI SANGYO KABUSHIKI KAISHA (JP) 1992-07-28 US disclosed
US-5082912-A For graft polymerization, surfactants TOMEI SANGYO KABUSHIKI KAISHA (JP) 1992-01-21 US disclosed
EP-0434362-A1 Graft copolymer, solution containing the graft copolymer, and method of treating contact lens with the solution Tomei Sangyo Kabushiki Kaisha (JP) 1991-06-26 EP disclosed
EP-0433046-A2 Polymer-type polymerization initiator Tomei Sangyo Kabushiki Kaisha (JP) 1991-06-19 EP disclosed
US-4868260-A OXYGEN PERMEABILITY TOMEI SANGYO KABUSHIKI KAISHA (JP) 1989-09-19 US disclosed
EP-0219884-A2 Hard contact lens material Tomei Sangyo Kabushiki Kaisha (JP) 1987-04-29 EP disclosed