Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 16/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 16/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 16/20 | 0.47 |
| ▸ | TSHR | P16473 | 14/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 14/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 11/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.47 |
| ▸ | USP2 | O75604 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 9/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27217728 | 0.87 | CYP1A2 (0.49) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL30813495 | 0.87 | CYP1A2 (0.49) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL27217635 | 0.84 | CYP1A2 (0.49) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL30813523 | 0.84 | CYP1A2 (0.49) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL30813471 | 0.82 | CYP1A2 (0.43) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL27217965 | 0.82 | CYP1A2 (0.43) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL21801347 | 0.79 | CYP1A2 (0.44) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL21801402 | 0.79 | CYP1A2 (0.44) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL30364043 | 0.78 | RET (0.55) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL30813386 | 0.78 | CYP1A2 (0.41) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240158394-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. | 2024-05-16 | — | — | US | disclosed |
| WO-2024059200-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. (US) | 2024-03-21 | — | — | WO | disclosed |
| CN-111971286-B | Substituted pyrrolo [2,3-d ] pyrimidine compounds as RET kinase inhibitors | 阿雷生物药品公司 | 2023-04-14 | — | — | CN | disclosed |
| US-11603374-B2 | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2023-03-14 | — | — | US | disclosed |
| EP-3740491-A1 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES COMPOUNDS AS RET KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2020-11-25 | — | — | EP | disclosed |
| CN-111971286-A | Substituted pyrrolo [2,3-d ] pyrimidine compounds as RET kinase inhibitors | 阿雷生物药品公司 | 2020-11-20 | — | — | CN | disclosed |
| US-20200339589-A1 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA, INC. | 2020-10-29 | — | — | US | disclosed |
| WO-2019143977-A1 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2019-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200339589-A1 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, FGFR3 | CYP1A2 3782/4885CYP3A4 4247/4885CYP2C19 3234/4885 |
| US-20240158394-A1 | NEK7 INHIBITORS | NEK7, NEK5, NEK1 | CYP1A2 4011/4885CYP3A4 3360/4885CYP2C19 4680/4885 |
| US-11603374-B2 | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors | RET, ROR1, FGFR3 | CYP1A2 3782/4885CYP3A4 4247/4885CYP2C19 3234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.