Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 14/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 14/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 14/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 12/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.43 |
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.43 |
| ▸ | USP2 | O75604 | 5/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 12/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31639478 | 0.87 | RET (0.55) | RETCYP1A2CYP3A4CYP2C19CYP2D6 | |
| Hydrochloric Acid SCHEMBL21178768 | 0.82 | RET (0.50) | RETCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL21178863 | 0.82 | RET (0.60) | RETCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL21178737 | 0.80 | RET (0.48) | RETCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL21178740 | 0.78 | CYP1A2 (0.47) | CYP1A2CYP3A4CYP2C19CYP2D6ALDH1A1 | |
| SCHEMBL21178952 | 0.77 | RET (0.57) | RETCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL30813471 | 0.74 | CYP1A2 (0.43) | CYP1A2CYP3A4CYP2C19CYP2D6ALDH1A1 | |
| SCHEMBL27217965 | 0.74 | CYP1A2 (0.43) | CYP1A2CYP3A4CYP2C19CYP2D6ALDH1A1 | |
| SCHEMBL29897211 | 0.74 | RET (0.57) | RETCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL21179025 | 0.74 | RET (0.57) | RETCYP1A2CYP3A4CYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025137605-A1 | COMPOUNDS FOR TARGETED DEGRADATION OF PROTO-ONCOGENE TYROSINE PROTEIN KINASE RECEPTOR | C4 THERAPEUTICS, INC. (US) | 2025-06-26 | — | — | WO | disclosed |
| CN-111971286-B | Substituted pyrrolo [2,3-d ] pyrimidine compounds as RET kinase inhibitors | 阿雷生物药品公司 | 2023-04-14 | — | — | CN | disclosed |