Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 6/20 | 0.42 |
| ▸ | PPARG | P37231 | 3/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | CTSS | P25774 | 3/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21539126 | 0.91 | ATM (0.46) | ATMCTSKPPARGPPARACTSS | |
| SCHEMBL30404606 | 0.87 | ATM (0.42) | ATMCTSKPPARGPPARACTSS | |
| SCHEMBL31282768 | 0.86 | ATM (0.39) | ATMCTSKPPARGPPARACTSS | |
| SCHEMBL30405268 | 0.85 | ATM (0.41) | ATMCTSKPPARGPPARACTSS | |
| SCHEMBL22409489 | 0.84 | ATM (0.48) | ATMCTSKPPARGPPARACTSS | |
| SCHEMBL22203002 | 0.84 | ATM (0.48) | ATMCTSKPPARGPPARACTSS | |
| SCHEMBL19014888 | 0.84 | ATM (0.48) | ATMCTSKPPARGPPARACTSS | |
| SCHEMBL30405523 | 0.84 | PPARA (0.41) | ATMCTSKPPARGPPARACTSS | |
| SCHEMBL2947311 | 0.83 | PLA2G2A (0.48) | ATMCTSKPPARGPPARACTSS | |
| SCHEMBL30404588 | 0.83 | ATM (0.41) | ATMCTSKPPARGPPARACTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3743069-A1 | BCL-2 PROTEINS DEGRADERS FOR CANCER TREATMENT | BioVentures, LLC (US) | 2020-12-02 | — | — | EP | disclosed |
| WO-2019144117-A1 | BCL-2 PROTEINS DEGRADERS FOR CANCER TREATMENT | BIOVENTURES, LLC (US) | 2019-07-25 | — | — | WO | disclosed |