Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 11/20 | 0.50 |
| ▸ | CCNH | P51946 | 11/20 | 0.50 |
| ▸ | CCNK | O75909 | 10/20 | 0.50 |
| ▸ | CDK12 | Q9NYV4 | 10/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.50 |
| ▸ | CDK9 | P50750 | 9/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.50 |
| ▸ | CDK2 | P24941 | 8/20 | 0.50 |
| ▸ | BRD4 | O60885 | 5/20 | 0.43 |
| ▸ | MNAT1 | P51948 | 7/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24176332 | 0.85 | CDK7 (0.45) | CDK7CCNHCCNKCDK12CCNT1 | |
| SCHEMBL29509294 | 0.85 | BRD4 (0.40) | CDK7CCNHCCNKCDK12CCNT1 | |
| SCHEMBL24087376 | 0.83 | CCNK (0.51) | CDK7CCNHCCNKCDK12CCNT1 | |
| SCHEMBL21188556 | 0.81 | CCNK (0.75) | CDK7CCNHCCNKCDK12CCNT1 | |
| SCHEMBL24176284 | 0.80 | CDK7 (0.46) | CDK7CCNHCCNKCDK12CCNT1 | |
| SCHEMBL21188147 | 0.75 | CCNK (0.74) | CDK7CCNHCCNKCDK12CCNT1 | |
| SCHEMBL30771954 | 0.75 | CDK7 (0.45) | CDK7CCNHCCNKCDK12CCNT1 | |
| SCHEMBL24176433 | 0.74 | CCNT1 (0.54) | CDK7CCNHCCNKCDK12CCNT1 | |
| SCHEMBL29509247 | 0.74 | CCNK (0.40) | CDK7CCNHCCNKCDK12CCNT1 | |
| SCHEMBL24176336 | 0.74 | CDK7 (0.46) | CDK7CCNHCCNKCDK12CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3740207-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2020-11-25 | — | — | EP | disclosed |
| WO-2019143719-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |