Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
| ▸ | SFRP1 | Q8N474 | 4/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 8/20 | 0.37 |
| ▸ | CCNH | P51946 | 8/20 | 0.37 |
| ▸ | MNAT1 | P51948 | 8/20 | 0.37 |
| ▸ | CCNK | O75909 | 6/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 6/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.37 |
| ▸ | CDK2 | P24941 | 4/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.37 |
| ▸ | CDK9 | P50750 | 3/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29509250 | 1.00 | HTR6 (0.42) | HTR6SFRP1CDK4CCND1CCND3 | |
| SCHEMBL30204140 | 0.92 | HTR6 (0.51) | HTR6SFRP1CDK4CCND1CCND3 | |
| SCHEMBL21179307 | 0.90 | CDK7 (0.44) | HTR6SFRP1BCHECDK7CCNH | |
| SCHEMBL29509115 | 0.90 | CDK7 (0.44) | HTR6SFRP1BCHECDK7CCNH | |
| SCHEMBL25595661 | 0.90 | CDK7 (0.44) | HTR6SFRP1BCHECDK7CCNH | |
| SCHEMBL21179301 | 0.83 | EGFR (0.37) | HTR6CDK4CCND1CCND3CDK6 | |
| SCHEMBL30204090 | 0.82 | CDK7 (0.44) | HTR6SFRP1BCHECDK7CCNH | |
| SCHEMBL29509294 | 0.81 | BRD4 (0.40) | HTR6SFRP1CDK4CCND1CCND3 | |
| SCHEMBL21178751 | 0.81 | CDK7 (0.46) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL30204102 | 0.81 | CCNK (0.47) | HTR6SFRP1BCHECDK7CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3740207-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2020-11-25 | — | — | EP | disclosed |
| WO-2019143719-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |