Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2120461 | 0.90 | CYP2C9 (0.50) | MAPTTP53SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL2117895 | 0.88 | MAPT (0.45) | MAPTTP53SMN1; SMN2ALDH1A1CYP2C9 | |
| SCHEMBL2118354 | 0.88 | MAPT (0.58) | MAPTTP53SMN1; SMN2ALDH1A1CYP2C9 | |
| SCHEMBL2119826 | 0.86 | MAPT (0.59) | MAPTSMN1; SMN2ALDH1A1GAACYP2C9 | |
| SCHEMBL2118662 | 0.82 | ALDH1A1 (0.61) | MAPTALDH1A1GAAGFERCYP2C9 | |
| SCHEMBL2120569 | 0.80 | MAPT (0.47) | MAPTTP53SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL2120080 | 0.79 | MCL1 (0.60) | MAPTTP53SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL2119832 | 0.79 | ALDH1A1 (0.47) | MAPTTP53SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL2119873 | 0.77 | IDH2 (0.45) | ALDH1A1GAAGFERCYP2C9LMNA | |
| SCHEMBL2119868 | 0.77 | POLB (0.46) | SMN1; SMN2ALDH1A1GAAGFERCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095024-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE | ELARA PHARMACEUTICALS GMBH (DE) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095024-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE | HIF1AN, HIF1A, EGLN2 | MAPT 4523/4885TP53 193/4885SMN1; SMN2 3684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.