Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 17/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14925523 | 0.74 | KDM4E (0.50) | ERN1 | |
| SCHEMBL2563604 | 0.71 | ERN1 (0.55) | ERN1 | |
| SCHEMBL28321998 | 0.68 | ERN1 (0.61) | ERN1 | |
| SCHEMBL31236213 | 0.68 | ERN1 (0.61) | ERN1 | |
| SCHEMBL7471060 | 0.67 | KDM4E (0.52) | ERN1 | |
| SCHEMBL2567378 | 0.67 | ALOX15 (0.47) | ERN1 | |
| SCHEMBL29111409 | 0.65 | ERN1 (0.56) | ERN1 | |
| SCHEMBL14916137 | 0.65 | HRH4 (0.66) | — | |
| SCHEMBL14916494 | 0.65 | ERN1 (0.55) | ERN1 | |
| SCHEMBL7682570 | 0.65 | ERN1 (0.47) | ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10357475-B2 | IRE-1α inhibitors | FOSUN ORINOVE PHARMATECH, INC. (CN) | 2019-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10357475-B2 | IRE-1α inhibitors | XBP1, ERN1, ERN2 | ERN1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.