SCHEMBL211809

SCHEMBL211809

CN1c2c[c]ccc2Sc2ccccc21

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.68
NOX1 Q9Y5S8 6/20 0.51
L3MBTL1 Q9Y468 2/20 0.51
ADRA2A P08913 2/20 0.51
ADRA2B P18089 2/20 0.51
ADRA2C P18825 2/20 0.51
CHRM3 P20309 2/20 0.51
SLC6A2 P23975 2/20 0.51
HTR2C P28335 2/20 0.51
SLC6A4 P31645 2/20 0.51
DRD3 P35462 2/20 0.51
HTR2B P41595 2/20 0.51
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
MAPT P10636 3/20 0.46
LMNA P02545 2/20 0.46
MAPK1 P28482 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
ALDH1A1 P00352 3/20 0.41
HPGD P15428 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL194182 0.89 MAOA (0.68) MAOANOX1L3MBTL1ADRA2AADRA2B
SCHEMBL231247 0.82 MAOA (1.00) MAOANOX1L3MBTL1ADRA2AADRA2B
SCHEMBL29377505 0.82 MAOA (1.00) MAOANOX1L3MBTL1ADRA2AADRA2B
SCHEMBL21409893 0.77 HDAC6 (0.45) MAOANOX1HTR2CDRD3HTR2B
SCHEMBL9639556 0.77 SNCA (0.61) MAOANOX1L3MBTL1ADRA2AADRA2B
SCHEMBL9658712 0.76 NOX1 (0.73) NOX1MAPTBCHE
SCHEMBL11567415 0.74 CYP2D6 (0.76) ADRA2AADRA2BADRA2CCHRM3SLC6A2
SCHEMBL21510221 0.72 MAOA (0.58) MAOANOX1L3MBTL1ADRA2AADRA2B
SCHEMBL129912 0.72 MAOA (0.37) MAOANOX1SLC6A2HTR2CMEN1
Perchlorate SCHEMBL11023648 0.72 MAOA (0.76) MAOANOX1L3MBTL1ADRA2AADRA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9249244-B2 Process for producing polydienes BRIDGESTONE CORPORATION (JP) 2016-02-02 US claimed
US-7671138-B2 Polymers functionized with hydrobenzamides BRIDGESTONE CORPORATION (JP) 2010-03-02 US claimed
US-20070276098-A1 Polymers functionalized with hydrobenzamide BRIDGESTONE CORPORATION 2007-11-29 US claimed
US-20070276122-A1 Polymers functionalized with hydrobenzamides BRIDGESTONE CORPORATION 2007-11-29 US claimed
EP-0130514-A2 Depot antiphlogistics Troponwerke GmbH & Co. KG (DE) 1985-01-09 EP claimed
US-9796800-B2 Process for producing polydienes BRIDGESTONE CORPORATION (JP) 2017-10-24 US disclosed
US-9650456-B2 Process for producing polydienes BRIDGESTONE CORPORATION (JP) 2017-05-16 US disclosed
EP-2658886-B1 BULK POLYMERIZATION OF CONJUGATED DIENES USING A NICKEL-BASED CATALYST SYSTEM BRIDGESTONE CORP (JP) 2017-03-08 EP disclosed
US-9546227-B2 Bulk polymerization of conjugated dienes using a nickel-based catalyst system BRIDGESTONE CORPORATION (JP) 2017-01-17 US disclosed
US-9505859-B2 Process for producing polydienes BRIDGESTONE CORPORATION (JP) 2016-11-29 US disclosed
EP-2658887-B1 BULK POLYMERIZATION OF CONJUGATED DIENES USING A NICKEL-BASED CATALYST SYSTEM BRIDGESTONE CORP (JP) 2016-11-16 EP disclosed
CN-104220466-B For the method preparing polydiene 株式会社普利司通 2016-09-21 CN disclosed
US-20090171046-A1 PROCESS FOR PRODUCING POLYDIENES BRIDGESTONE CORPORATION (JP) 2009-07-02 US disclosed
EP-2075267-A2 Process for producing polydienes Bridgestone Corporation (JP) 2009-07-01 EP disclosed
WO-2008156804-A2 MODIFIED ASPHALT BINDERS AND ASPHALT PAVING COMPOSITIONS FIRESTONE POLYMERS LLC (US) 2008-12-24 WO disclosed
US-20080146745-A1 POLYMERS FUNCTIONALIZED WITH PROTECTED OXIME COMPOUNDS BRIDGESTONE CORPORATION (JP) 2008-06-19 US disclosed
US-20070276122-A1 Polymers functionalized with hydrobenzamides BRIDGESTONE CORPORATION 2007-11-29 US disclosed
US-20070276098-A1 Polymers functionalized with hydrobenzamide BRIDGESTONE CORPORATION 2007-11-29 US disclosed
CN-1726026-A Antioxidants for Fats, Oils and Foods CIBA SC HOLDING AG (CH) 2006-01-25 CN disclosed
US-4362738-A ANTIINFLAMMATORIES DR. KARL THOMAE GMBH (DE) 1982-12-07 US disclosed