Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 4/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CCNK | O75909 | 2/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 4/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | ROS1 | P08922 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24428388 | 0.80 | EGLN2 (0.32) | EGLN2TRPA1TNFIRAK4 | |
| SCHEMBL21181313 | 0.80 | HCRTR2 (0.41) | METMAPK1ROCK2CLK1 | |
| SCHEMBL21174244 | 0.78 | EGLN2 (0.37) | METEGLN2TRPA1CCNKCDK12 | |
| SCHEMBL21174206 | 0.73 | EGLN2 (0.39) | METEGLN2CCNKCDK12CCNA2 | |
| SCHEMBL21174099 | 0.73 | EGLN2 (0.39) | METEGLN2MAPK1CCNKCDK12 | |
| SCHEMBL21174192 | 0.70 | EGLN2 (0.37) | METEGLN2MAPK1CCNKCDK12 | |
| SCHEMBL21174111 | 0.68 | EGLN2 (0.40) | METEGLN2CCNKCDK12CCNA2 | |
| SCHEMBL21174182 | 0.68 | EGLN2 (0.40) | METEGLN2CCNKCDK12CCNA2 | |
| SCHEMBL21174367 | 0.68 | MET (0.44) | METMAPK1ROS1ALKCLK1 | |
| SCHEMBL21181132 | 0.65 | MET (0.39) | METMAPK1ROCK2CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3514149-B1 | HETEROCYCLIC AMIDE COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2022-05-18 | — | — | EP | disclosed |
| EP-3514149-A1 | HETEROCYCLIC AMIDE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2019-07-24 | — | — | EP | disclosed |