Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rosiglitazone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 12/20 | 0.98 |
| ▸ | RXRA | P19793 | 2/20 | 0.98 |
| ▸ | RARG | P13631 | 1/20 | 0.98 |
| ▸ | PPARA | Q07869 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rosiglitazone SCHEMBL5274486 | 0.99 | PPARG (0.96) | PPARGRXRARARGPPARAKMT2A | |
| Rosiglitazone SCHEMBL3378536 | 0.99 | PPARG (0.96) | PPARGRXRARARGPPARAKMT2A | |
| Rosiglitazone SCHEMBL29376790 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAKMT2A | |
| Rosiglitazone SCHEMBL5734118 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAKMT2A | |
| Rosiglitazone SCHEMBL29757195 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAKMT2A | |
| Rosiglitazone SCHEMBL466397 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAKMT2A | |
| Rosiglitazone SCHEMBL19023 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAKMT2A | |
| Rosiglitazone SCHEMBL504723 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAKMT2A | |
| Rosiglitazone SCHEMBL5556077 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAKMT2A | |
| Rosiglitazone SCHEMBL19469505 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250092360-A1 | METHODS AND COMPOSITIONS FOR GENERATING SOMATOSTATIN+ INTERNEURONS FROM HUMAN FOREBRAIN NEURAL PROGENITOR CELLS | TRAILHEAD BIOSYSTEMS INC. | 2025-03-20 | — | — | US | claimed |
| CN-117188045-A | Multilayer nanofiber membrane, preparation method thereof and application thereof in diabetes wound dressing | 华南农业大学 | 2023-12-08 | — | — | CN | claimed |
| CN-113024537-A | Impurity removal method for rosiglitazone hydrochloride | 乳源东阳光药业有限公司 | 2021-06-25 | — | — | CN | claimed |
| CN-111693640-A | Screening method for illegally added compounds in health food | 劲牌有限公司 | 2020-09-22 | — | — | CN | claimed |
| WO-2010013141-A2 | SUBSTANTIALLY PURE ROSIGLITAZONE HYDROGEN SULFATE | ACTAVIS GROUP PTC EHF (IS) | 2010-02-04 | — | — | WO | claimed |
| EP-1853262-A1 | PHARMACEUTICAL COMPOSITION COMPRISING AMORPHOUS ROSIGLITAZONE | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-14 | — | — | EP | claimed |
| WO-2006125402-A1 | A PROCESS FOR THE CRYSTALLIZATION OF ROSIGLITAZONE AND ITS DERIVATIVES FROM MIXED SOLVENTS | ZENTIVA, A.S. (CZ) | 2006-11-30 | — | — | WO | claimed |
| WO-2006090150-A1 | PHARMACEUTICAL COMPOSITION COMPRISING AMORPHOUS ROSIGLITAZONE | SMITHKLINE BEECHAM CORPORATION (US) | 2006-08-31 | — | — | WO | claimed |
| US-20060083784-A1 | Amorphous pharmaceutical compositions | SMITHKLINE BEECHAM CORPORATION | 2006-04-20 | — | — | US | claimed |
| EP-1278513-A4 | A CORE FORMULATION | AEROPHARM TECHNOLOGY INC (US) | 2005-01-26 | — | — | EP | claimed |
| EP-1278513-A2 | A CORE FORMULATION | Aeropharm Technology Incorporated (US) | 2003-01-29 | — | — | EP | claimed |
| WO-2001082867-A2 | A CORE FORMULATION | AEROPHARM TECHNOLOGY, INC. (US) | 2001-11-08 | — | — | WO | claimed |
| CN-1277965-A | Luogelie ketone hydrochloride and its use | CHINA PHARMACEUTICAL RES & DEV (CN) | 2000-12-27 | — | — | CN | claimed |
| US-20250092360-A1 | METHODS AND COMPOSITIONS FOR GENERATING SOMATOSTATIN+ INTERNEURONS FROM HUMAN FOREBRAIN NEURAL PROGENITOR CELLS | TRAILHEAD BIOSYSTEMS INC. | 2025-03-20 | — | — | US | disclosed |
| EP-4015000-B1 | COMBINATION PRODUCT CONTAINING LIMONIN COMPOUND AND THIAZOLIDINEDIONE | ZHEJIANG YANGSHENGTANG INST OF NATURAL MEDICATION CO LTD (CN) | 2025-01-01 | — | — | EP | disclosed |
| CN-118948849-A | Medicine for preventing and treating diseases related to anti-obesity effect | 盐野义制药株式会社 | 2024-11-15 | — | — | CN | disclosed |
| EP-1278513-A4 | A CORE FORMULATION | AEROPHARM TECHNOLOGY INC (US) | 2005-01-26 | — | — | EP | disclosed |
| EP-1278513-A2 | A CORE FORMULATION | Aeropharm Technology Incorporated (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001082867-A2 | A CORE FORMULATION | AEROPHARM TECHNOLOGY, INC. (US) | 2001-11-08 | — | — | WO | disclosed |
| CN-1277965-A | Luogelie ketone hydrochloride and its use | CHINA PHARMACEUTICAL RES & DEV (CN) | 2000-12-27 | — | — | CN | disclosed |