Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rosiglitazone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 12/20 | 1.00 |
| ▸ | RARG | P13631 | 1/20 | 1.00 |
| ▸ | RXRA | P19793 | 1/20 | 1.00 |
| ▸ | PPARA | Q07869 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rosiglitazone SCHEMBL19023 | 1.00 | PPARG (1.00) | PPARGRARGRXRAPPARAKMT2A | |
| Rosiglitazone SCHEMBL29376790 | 1.00 | PPARG (1.00) | PPARGRARGRXRAPPARAKMT2A | |
| Rosiglitazone SCHEMBL19469505 | 1.00 | PPARG (1.00) | PPARGRARGRXRAPPARAKMT2A | |
| Rosiglitazone SCHEMBL122053 | 1.00 | PPARG (1.00) | PPARGRARGRXRAPPARAKMT2A | |
| Rosiglitazone SCHEMBL466397 | 1.00 | PPARG (1.00) | PPARGRARGRXRAPPARAKMT2A | |
| Rosiglitazone SCHEMBL5556077 | 1.00 | PPARG (1.00) | PPARGRARGRXRAPPARAKMT2A | |
| Rosiglitazone SCHEMBL504723 | 1.00 | PPARG (1.00) | PPARGRARGRXRAPPARAKMT2A | |
| Rosiglitazone SCHEMBL29757195 | 1.00 | PPARG (1.00) | PPARGRARGRXRAPPARAKMT2A | |
| Rosiglitazone SCHEMBL3629161 | 0.99 | PPARG (0.98) | PPARGRARGRXRAPPARAKMT2A | |
| Rosiglitazone SCHEMBL3347673 | 0.99 | PPARG (0.98) | PPARGRARGRXRAPPARAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1315721-B1 | A THIAZOLIDINEDIONE DERIVATIVE AND ITS USE AS ANTIDIABETIC | SMITHKLINE BEECHAM PLC (GB) | 2006-10-25 | — | — | EP | claimed |
| US-20040014791-A1 | Thiazolidinedione derivative and its use as antidiabetic | RECOMGENEX KFT. (HU) | 2004-01-22 | — | — | US | claimed |
| EP-1315721-A1 | A THIAZOLIDINEDIONE DERIVATIVE AND ITS USE AS ANTIDIABETIC | SMITHKLINE BEECHAM PLC (GB) | 2003-06-04 | — | — | EP | claimed |
| WO-2002020517-A1 | A THIAZOLIDINEDIONE DERIVATIVE AND ITS USE AS ANTIDIABETIC | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-03-14 | — | — | WO | claimed |
| EP-1315721-B1 | A THIAZOLIDINEDIONE DERIVATIVE AND ITS USE AS ANTIDIABETIC | SMITHKLINE BEECHAM PLC (GB) | 2006-10-25 | — | — | EP | disclosed |
| US-20040014791-A1 | Thiazolidinedione derivative and its use as antidiabetic | RECOMGENEX KFT. (HU) | 2004-01-22 | — | — | US | disclosed |
| EP-1315721-A1 | A THIAZOLIDINEDIONE DERIVATIVE AND ITS USE AS ANTIDIABETIC | SMITHKLINE BEECHAM PLC (GB) | 2003-06-04 | — | — | EP | disclosed |
| WO-2002020517-A1 | A THIAZOLIDINEDIONE DERIVATIVE AND ITS USE AS ANTIDIABETIC | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-03-14 | — | — | WO | disclosed |