Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 17/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 17/20 | 0.42 |
| ▸ | CDK7 | P50613 | 12/20 | 0.42 |
| ▸ | CCNH | P51946 | 12/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 10/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.42 |
| ▸ | CDK2 | P24941 | 10/20 | 0.42 |
| ▸ | CDK9 | P50750 | 10/20 | 0.42 |
| ▸ | MNAT1 | P51948 | 10/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30957590 | 0.87 | TDO2 (0.47) | CCNKCDK12CDK7CCNHCCNT1 | |
| SCHEMBL24900493 | 0.87 | TDO2 (0.47) | CCNKCDK12CDK7CCNHCCNT1 | |
| SCHEMBL21629046 | 0.86 | CCNK (0.44) | CCNKCDK12CDK7CCNHCCNT1 | |
| SCHEMBL30260854 | 0.86 | CLK1 (0.50) | CCNKCDK12CDK7CCNHCCNT1 | |
| SCHEMBL21178668 | 0.86 | CLK1 (0.50) | CCNKCDK12CDK7CCNHCCNT1 | |
| SCHEMBL30554768 | 0.86 | CCNK (0.44) | CCNKCDK12CDK7CCNHCCNT1 | |
| SCHEMBL25597321 | 0.86 | CLK1 (0.52) | CCNKCDK12CDK7CCNHCCNT1 | |
| SCHEMBL21178905 | 0.83 | CCNK (0.60) | CCNKCDK12CDK7CCNHCCNT1 | |
| SCHEMBL17683297 | 0.83 | GSK3B (0.47) | CCNKCDK12CDK7CCNHCCNT1 | |
| SCHEMBL30261038 | 0.83 | GSK3B (0.47) | CCNKCDK12CDK7CCNHCCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143730-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |