Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32677509 | 0.87 | KDM4D (0.42) | ALDH1A1NAMPTKMT2AL3MBTL1DRD2 | |
| SCHEMBL32677506 | 0.87 | KDM4D (0.42) | ALDH1A1NAMPTKMT2AL3MBTL1DRD2 | |
| SCHEMBL3701445 | 0.86 | NAMPT (0.43) | NAMPTKMT2AL3MBTL1DRD2KDM1A | |
| SCHEMBL19380850 | 0.86 | KMT2A (0.51) | NAMPTKMT2AL3MBTL1DRD2KDM1A | |
| SCHEMBL32677525 | 0.85 | NAMPT (0.42) | NAMPTKMT2AL3MBTL1DRD2KDM1A | |
| SCHEMBL32677522 | 0.85 | NAMPT (0.42) | NAMPTKMT2AL3MBTL1DRD2KDM1A | |
| SCHEMBL19380845 | 0.84 | NAMPT (0.41) | NAMPTKMT2AL3MBTL1DRD2KDM1A | |
| SCHEMBL12321516 | 0.83 | DRD2 (0.48) | NAMPTKMT2AL3MBTL1DRD2KDM1A | |
| SCHEMBL3707832 | 0.82 | DRD2 (0.49) | MAPTALDH1A1NAMPTKMT2AL3MBTL1 | |
| SCHEMBL32677535 | 0.81 | NAMPT (0.38) | NAMPTKMT2AL3MBTL1DRD2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111247119-B | Amidine and guanidine derivatives, preparation method and application thereof in medicines | 四川科伦博泰生物医药股份有限公司 | 2023-02-03 | — | — | CN | disclosed |
| WO-2019141095-A1 | AMIDINE AND GUANIDINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2019-07-25 | — | — | WO | disclosed |