Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Chloroform. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chloroform SCHEMBL1065585 | 1.00 | TSHR (0.55) | — | |
| Chloroform SCHEMBL2169183 | 0.96 | TSHR (0.50) | — | |
| Chloroform SCHEMBL6508789 | 0.96 | — | — | |
| Chloroform SCHEMBL35119 | 0.95 | — | — | |
| Chloroform SCHEMBL8927139 | 0.95 | TSHR (0.60) | — | |
| Chloroform SCHEMBL7542887 | 0.95 | TSHR (0.60) | — | |
| Chloroform SCHEMBL7542885 | 0.95 | TSHR (0.60) | — | |
| Chloroform SCHEMBL2819782 | 0.95 | TSHR (0.60) | — | |
| Chloroform SCHEMBL8192102 | 0.95 | TSHR (0.60) | — | |
| Chloroform SCHEMBL8927142 | 0.95 | TSHR (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106831341-B | Method for rectifying and separating chloroform-ethanol-water mixed solution by side line discharging under extraction azeotropy | 南京师范大学 | 2020-07-14 | — | — | CN | claimed |
| CN-105669604-B | A method of wildness hazel-mushroom taxol is purified using ultra high pressure extraction, biological enzymolysis, adverse current chromatogram | 大兴安岭富林山野珍品科技开发有限责任公司 | 2018-12-25 | — | — | CN | claimed |
| CN-106967147-A | C27Spirostan type steroid saponin compounds and its pharmaceutical composition and its application | 中国科学院昆明植物研究所 | 2017-07-21 | — | — | CN | claimed |
| CN-106928164-A | A kind of separation method of tetrahydrofuran ethanol water toluene mixed solution | 南京师范大学 | 2017-07-07 | — | — | CN | claimed |
| CN-106831341-A | A kind of method that lateral line discharging rectifying separates chloroform alcohol water mixed liquid under extraction azeotropic | 南京师范大学 | 2017-06-13 | — | — | CN | claimed |
| CN-105669604-A | New method for purifying wild hazel-mushroom taxol through ultrahigh-pressure extraction, biological enzymolysis and countercurrent chromatography | 大兴安岭富林山野珍品科技开发有限责任公司 | 2016-06-15 | — | — | CN | claimed |
| CN-104109403-B | Wild blueberry anthocyanidin extracts, Novel purification method | DAXINGANLING SHENZHOU NORTH POLE BLUEBERRY BIOLOGICAL ENGINEERING CO., LTD. (CN) | 2016-04-20 | — | — | CN | claimed |
| CN-102657594-B | Application of toad peptide antibiotics in toothpaste preparation | HARBIN INST OF TECHNOLOGY | 2013-08-07 | — | — | CN | claimed |
| CN-102657594-A | Application of toad peptide antibiotics in toothpaste preparation | HARBIN INST OF TECHNOLOGY | 2012-09-12 | — | — | CN | claimed |
| US-4378348-A | PRODUCED FROM STREPTOMYCES HYGROSCOPICUS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1983-03-29 | — | — | US | claimed |
| US-4303646-A | BIOSYNTHESIS BY ACTINOPLANES; GLYOPEPTIDE | GRUPPO LEPETIT S.P.A. (IT) | 1981-12-01 | — | — | US | claimed |
| WO-2024108643-A1 | METHOD FOR SIMULTANEOUSLY PREPARING SPECIFIC PHOSPHATIDYLCHOLINE AND PHOSPHATIDYLETHANOLAMINE | 广州白云山汉方现代药业有限公司 | 2024-05-30 | — | — | WO | disclosed |
| CN-118084964-A | Method for simultaneously preparing specific phosphatidylcholine and phosphatidylethanolamine | 广州白云山汉方现代药业有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-114262505-B | Preparation method of optical-grade fog-adding PET film | 江苏软讯科技有限公司 | 2023-06-16 | — | — | CN | disclosed |
| CN-109589341-B | Gryllotalpa extract and its preparation method | 上海医药工业研究院 | 2022-07-12 | — | — | CN | disclosed |
| US-4148880-A | ANIMAL GROWTH PROMOTANTS | PFIZER INC. (US) | 1979-04-10 | — | — | US | disclosed |
| US-4130571-A | Process for preparing 1,2-diacyl-3-glycerylphosphorylcholines | NIPPON SHOJI KAISHA, LTD. (JP) | 1978-12-19 | — | — | US | disclosed |
| US-4108855-A | Compounds of ergolene and ergoline structure and method for the preparation thereof | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1978-08-22 | — | — | US | disclosed |
| US-4038383-A | MIXTURE OF ANTIBIOTICS PRODUCED BY A SPECIES OF ACTINOPLANES | PFIZER INC. (US) | 1977-07-26 | — | — | US | disclosed |
| US-4001397-A | AEROBIC FERMENTATION OF ACTINOPLANES NIPPONENSIS | PFIZER INC. (US) | 1977-01-04 | — | — | US | disclosed |