Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 7/20 | 0.38 |
| ▸ | PRKDC | P78527 | 7/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21178138 | 1.00 | SYK (0.47) | SYKIRAK4TBK1PRKDCPDE10A | |
| SCHEMBL30817825 | 1.00 | SYK (0.47) | SYKIRAK4TBK1PRKDCPDE10A | |
| SCHEMBL21177871 | 0.88 | SYK (0.47) | SYKIRAK4TBK1PRKDCPDE10A | |
| SCHEMBL21187399 | 0.88 | SYK (0.47) | SYKIRAK4TBK1PRKDCPDE10A | |
| SCHEMBL30823276 | 0.88 | SYK (0.47) | SYKIRAK4TBK1PRKDCPDE10A | |
| SCHEMBL21187340 | 0.88 | IRAK4 (0.38) | SYKIRAK4TBK1PRKDCPDE10A | |
| SCHEMBL21187330 | 0.85 | TBK1 (0.43) | SYKTBK1 | |
| SCHEMBL30823312 | 0.85 | TBK1 (0.43) | SYKTBK1 | |
| SCHEMBL21177888 | 0.85 | TBK1 (0.43) | SYKTBK1 | |
| SCHEMBL21177847 | 0.82 | SYK (0.43) | SYKIRAK4TBK1PRKDCPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143678-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-07-25 | — | — | WO | disclosed |