Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 7/20 | 0.49 |
| ▸ | CYP4F2 | P78329 | 4/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 4/20 | 0.43 |
| ▸ | POLQ | O75417 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 3/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14726450 | 0.83 | GAA (0.47) | RETCYP4F2CYP4A11GAAALDH1A1 | |
| SCHEMBL26112762 | 0.82 | RET (0.45) | RETCYP4F2CYP4A11POLQGAA | |
| SCHEMBL21185044 | 0.81 | RET (0.50) | RETCYP4F2CYP4A11POLQGAA | |
| SCHEMBL3500980 | 0.80 | ALDH1A1 (0.49) | RETCYP4F2CYP4A11GAAALDH1A1 | |
| SCHEMBL22449667 | 0.80 | CYP4F2 (0.44) | RETCYP4F2CYP4A11GAAALDH1A1 | |
| SCHEMBL19204921 | 0.80 | CYP4F2 (0.44) | RETCYP4F2CYP4A11GAAALDH1A1 | |
| SCHEMBL21191295 | 0.79 | CYP4F2 (0.43) | RETCYP4F2CYP4A11GAAALDH1A1 | |
| SCHEMBL25407969 | 0.78 | RET (0.43) | RETCYP4F2CYP4A11POLQGAA | |
| SCHEMBL25297100 | 0.78 | RET (0.43) | RETCYP4F2CYP4A11POLQGAA | |
| SCHEMBL14638243 | 0.78 | CYP4F2 (0.43) | RETCYP4F2CYP4A11GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143977-A1 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2019-07-25 | — | — | WO | disclosed |
| WO-2019143994-A1 | SUBSTITUTED PYRAZOLYL[4,3-C]PYRIDINECOMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2019-07-25 | — | — | WO | disclosed |