Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | PAK4 | O96013 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | INSR | P06213 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | FES | P07332 | 1/20 | 0.31 |
| ▸ | ROS1 | P08922 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | FER | P16591 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21874330 | 0.73 | APP (0.41) | APPAXLNUDT1PIK3C3SYK | |
| SCHEMBL12205185 | 0.71 | NCF1 (0.47) | APPBRD4AXLNUDT1CDK8 | |
| SCHEMBL21088541 | 0.71 | APP (0.35) | APPBRD4AXLNUDT1PIK3C3 | |
| SCHEMBL12128989 | 0.70 | APP (0.56) | APPBRD4AXLNUDT1PLK4 | |
| Hydrochloric Acid SCHEMBL4979021 | 0.70 | NCF1 (0.45) | APPBRD4AXLNUDT1CDK8 | |
| SCHEMBL21961534 | 0.68 | GSK3B (0.40) | APP | |
| SCHEMBL29510819 | 0.68 | GSK3B (0.40) | APP | |
| SCHEMBL30009820 | 0.68 | HPGD (0.57) | — | |
| SCHEMBL417409 | 0.67 | APP (0.42) | APPBRD4AXLNUDT1CDK8 | |
| SCHEMBL12225026 | 0.67 | APP (0.42) | APPBRD4AXLNUDT1CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019143719-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2019-07-25 | — | — | WO | disclosed |