Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 9/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19851024 | 0.86 | SLC22A12 (0.60) | SLC22A12CYP2C9CYP2C19CYP3A4ALDH1A1 | |
| SCHEMBL19851023 | 0.85 | SLC22A12 (0.59) | SLC22A12CYP2C9CYP2C19CYP3A4ALDH1A1 | |
| SCHEMBL23954462 | 0.78 | SLC22A12 (0.43) | SLC22A12CYP2C9CYP3A4ALDH1A1TSHR | |
| SCHEMBL19047054 | 0.76 | SLC22A12 (0.76) | SLC22A12CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL19851014 | 0.76 | SLC22A12 (0.76) | SLC22A12CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL19851020 | 0.76 | SLC22A12 (0.74) | SLC22A12CYP2C9CYP2C19CYP3A4ALDH1A1 | |
| SCHEMBL19851101 | 0.74 | ALDH1A1 (0.48) | SLC22A12CYP2C9CYP3A4ALDH1A1TSHR | |
| SCHEMBL21094241 | 0.74 | SLC22A12 (0.51) | SLC22A12CYP2C9CYP2C19CYP3A4ALDH1A1 | |
| SCHEMBL19851126 | 0.74 | SLC22A12 (0.63) | SLC22A12CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL19851096 | 0.74 | TSHR (0.56) | CYP2C9CYP3A4ALDH1A1PLA2G1BNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10399978-B2 | Imidazopyridine thioglycolic acid derivatives as potent inhibitors of human urate transporter 1 | SHANDONG UNIVERSITY (CN) | 2019-09-03 | — | — | US | disclosed |
| US-20190225606-A1 | Novel Imidazopyridine Thioglycolic Acid Derivatives as Potent Inhibitors of Human Urate Transporter 1 | SHANDONG UNIVERSITY (CN) | 2019-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190225606-A1 | Novel Imidazopyridine Thioglycolic Acid Derivatives as Potent Inhibitors of Human Urate Transporter 1 | SLC29A1, SLC28A1, SLC5A1 | SLC22A12 118/4885CYP2C9 292/4885CYP2C19 1044/4885 |
| US-10399978-B2 | Imidazopyridine thioglycolic acid derivatives as potent inhibitors of human urate transporter 1 | SLC29A1, SLC28A1, SLC5A1 | SLC22A12 163/4885CYP2C9 254/4885CYP2C19 907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.