Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 11/20 | 0.38 |
| ▸ | MTTP | P55157 | 2/20 | 0.35 |
| ▸ | APOB | P04114 | 1/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
| ▸ | GRK2 | P25098 | 1/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21189291 | 0.92 | NPC1 (0.41) | ALDH1A1NPC1RAB9AGRM4MTTP | |
| SCHEMBL21189297 | 0.91 | ALDH1A1 (0.44) | ALDH1A1NAAAMEN1NPC1RAB9A | |
| SCHEMBL19973485 | 0.89 | ALDH1A1 (0.41) | ALDH1A1GRM4MTTPAPOBSMO | |
| SCHEMBL19973486 | 0.89 | ALDH1A1 (0.41) | ALDH1A1GRM4MTTPAPOBSMO | |
| SCHEMBL21189277 | 0.87 | GRM4 (0.37) | GRM4P2RX7 | |
| SCHEMBL19973517 | 0.85 | NPC1 (0.46) | MEN1NPC1RAB9AKMT2AMTTP | |
| SCHEMBL19973515 | 0.85 | NPC1 (0.46) | MEN1NPC1RAB9AKMT2AMTTP | |
| SCHEMBL21189208 | 0.85 | NPC1 (0.42) | ALDH1A1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL26714839 | 0.85 | NPC1 (0.42) | ALDH1A1NPC1RAB9AGRM4MTTP | |
| SCHEMBL21189365 | 0.84 | GRM4 (0.35) | NPC1RAB9AGRM4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11001564-B2 | Substituted chromane-8-carboxamide compounds and analogues thereof, and methods using same | ARBUTUS BIOPHARMA CORPORATION (CA) | 2021-05-11 | — | — | US | disclosed |
| US-20190225593-A1 | SUBSTITUTED CHROMANE-8-CARBOXAMIDE COMPOUNDS AND ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORP (CA) | 2019-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190225593-A1 | SUBSTITUTED CHROMANE-8-CARBOXAMIDE COMPOUNDS AND ANALOGUES THEREOF, AND METHODS USING SAME | CBX8, HAVCR2, HCCS | ALDH1A1 3241/4885NAAA 653/4885MEN1 1933/4885 |
| US-11001564-B2 | Substituted chromane-8-carboxamide compounds and analogues thereof, and methods using same | CBX8, HAVCR2, HCCS | ALDH1A1 3241/4885NAAA 653/4885MEN1 1933/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.