Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 4/20 | 0.48 |
| ▸ | PDE4A | P27815 | 4/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29866760 | 1.00 | CHRM3 (0.48) | CHRM3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21200767 | 0.85 | KDM4E (0.48) | CHRM3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29867435 | 0.85 | KDM4E (0.48) | CHRM3PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL5220791 | 0.82 | CHRM3 (0.47) | CHRM3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21211937 | 0.81 | CHRM3 (0.54) | CHRM3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29867676 | 0.78 | OPRM1 (0.36) | CHRM3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21200131 | 0.77 | SMYD3 (0.35) | CHRM3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL31079081 | 0.77 | TP53 (0.47) | HRH4KDM4EALDH1A1KMT2AHRH3 | |
| SCHEMBL21200816 | 0.76 | KHK (0.43) | CHRM3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5220789 | 0.75 | CKS1B (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3743063-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | Nurix Therapeutics, Inc. (US) | 2020-12-02 | — | — | EP | disclosed |
| WO-2019148005-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | NURIX THERAPEUTICS, INC. (US) | 2019-08-01 | — | — | WO | disclosed |