Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.48 |
| ▸ | TNKS | O95271 | 1/20 | 0.48 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21200646 | 1.00 | HCAR2 (0.48) | HCAR2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8746675 | 0.79 | HCAR2 (0.64) | HCAR2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8746677 | 0.79 | HCAR2 (0.64) | HCAR2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1251511 | 0.78 | HDAC3 (0.52) | HCAR2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1251510 | 0.78 | HDAC3 (0.52) | HCAR2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2134058 | 0.77 | KDM4E (0.53) | HCAR2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2134056 | 0.77 | KDM4E (0.53) | HCAR2HDAC3HDAC4HDAC1HDAC7 | |
| Hydrochloric Acid SCHEMBL6818359 | 0.77 | HDAC3 (0.50) | HCAR2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6023835 | 0.75 | PKM (0.55) | HCAR2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1167211 | 0.75 | HCAR2 (0.48) | HCAR2HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3743063-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | Nurix Therapeutics, Inc. (US) | 2020-12-02 | — | — | EP | disclosed |
| WO-2019148005-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | NURIX THERAPEUTICS, INC. (US) | 2019-08-01 | — | — | WO | disclosed |