Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | STAT6 | P42226 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21200362 | 1.00 | CYP19A1 (0.35) | CYP19A1CYP17A1KDM1AHDAC1HDAC6 | |
| SCHEMBL29866369 | 1.00 | CYP19A1 (0.35) | CYP19A1CYP17A1KDM1AHDAC1HDAC6 | |
| SCHEMBL29102829 | 0.86 | AR (0.35) | CYP19A1CYP17A1KDM1AHDAC1HDAC6 | |
| SCHEMBL27752251 | 0.81 | SMARCA2 (0.38) | CYP19A1CYP17A1TSHRCYP3A4KDM4E | |
| SCHEMBL27845906 | 0.76 | KDM1A (0.37) | KDM1AHDAC1HDAC6ARKDM4E | |
| SCHEMBL10516365 | 0.75 | CYP19A1 (0.54) | CYP19A1CYP17A1TSHRCYP3A4USP2 | |
| SCHEMBL20719609 | 0.75 | FDFT1 (0.34) | CYP19A1CYP17A1TSHRCYP3A4KDM4E | |
| SCHEMBL24031007 | 0.75 | PTGS2 (0.46) | TSHRCYP3A4KDM4ELMNAHIF1A | |
| SCHEMBL8241576 | 0.75 | KDM1A (0.36) | KDM1AHDAC1HDAC6ARKDM4E | |
| SCHEMBL25810655 | 0.74 | PTGS1 (0.47) | CYP19A1KDM1AHDAC1HDAC6AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3743063-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | Nurix Therapeutics, Inc. (US) | 2020-12-02 | — | — | EP | disclosed |
| WO-2019148005-A1 | INHIBITORS OF CBL-B AND METHODS OF USE THEREOF | NURIX THERAPEUTICS, INC. (US) | 2019-08-01 | — | — | WO | disclosed |
| CN-103403001-A | Novel heterocyclic derivatives and their use in the treatment of neurological disorders | NOVARTIS AG | 2013-11-20 | — | — | CN | disclosed |