Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.32 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.32 |
| ▸ | RARA | P10276 | 2/20 | 0.32 |
| ▸ | RARG | P13631 | 2/20 | 0.32 |
| ▸ | RARB | P10826 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21201833 | 1.00 | NNMT (0.45) | NNMTALDH1A1KDM4EALOX15HSD17B10 | |
| SCHEMBL21201875 | 0.82 | NNMT (0.34) | NNMTALDH1A1KDM4EALOX15HSD17B10 | |
| SCHEMBL21201839 | 0.82 | PDE10A (0.36) | NNMTALDH1A1MAPK1PDE10AMGAM | |
| SCHEMBL21201876 | 0.82 | PDE10A (0.36) | NNMTALDH1A1MAPK1PDE10AMGAM | |
| SCHEMBL21312953 | 0.82 | NNMT (0.34) | NNMTALDH1A1KDM4EALOX15HSD17B10 | |
| SCHEMBL21201853 | 0.82 | NNMT (0.34) | NNMTALDH1A1KDM4EALOX15HSD17B10 | |
| SCHEMBL21201859 | 0.79 | MGAM (0.38) | ALDH1A1MAPK1MGAMMAPTLTB4R | |
| SCHEMBL21201820 | 0.79 | MGAM (0.38) | ALDH1A1MAPK1MGAMMAPTLTB4R | |
| SCHEMBL20797488 | 0.76 | PDE10A (0.35) | NNMTPDE10A | |
| SCHEMBL2459207 | 0.76 | PDE10A (0.37) | NNMTPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190263828-A1 | HETEROAROMATIC COMPOUNDS AS VANIN INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2019-08-29 | — | — | US | disclosed |
| US-10364255-B2 | Heteroaromatic compounds as Vanin inhibitors | BOEHRINGER INGLEHEIM INTERNATIONAL GMBH (DE) | 2019-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190263828-A1 | HETEROAROMATIC COMPOUNDS AS VANIN INHIBITORS | VHL, FANCI, UGT2B7 | NNMT 2011/4885ALDH1A1 583/4885KDM4E 3374/4885 |
| US-10364255-B2 | Heteroaromatic compounds as Vanin inhibitors | VHL, FANCI, UGT2B7 | NNMT 2011/4885ALDH1A1 583/4885KDM4E 3374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.