Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.59 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22166487 | 0.78 | NOTUM (0.60) | NOTUMTSHRL3MBTL1MAPTESR1 | |
| SCHEMBL10022397 | 0.77 | NOTUM (1.00) | NOTUMTSHRMAPTHPGDALDH1A1 | |
| SCHEMBL22312193 | 0.73 | TSHR (0.55) | NOTUMTSHRL3MBTL1MAPTESR1 | |
| SCHEMBL614454 | 0.68 | NOTUM (0.63) | NOTUMTSHRMAPTHPGDALDH1A1 | |
| SCHEMBL10168904 | 0.68 | CA12 (0.50) | L3MBTL1MAPTPOLBALDH1A1LMNA | |
| SCHEMBL26915283 | 0.67 | RAB9A (0.50) | TSHRMAPTPOLBHPGDALDH1A1 | |
| SCHEMBL69432 | 0.67 | NOTUM (0.60) | NOTUMTSHRL3MBTL1MAPTALDH1A1 | |
| SCHEMBL21347448 | 0.67 | CYP2C9 (0.50) | L3MBTL1MAPTHPGDALDH1A1KDM4E | |
| SCHEMBL28268977 | 0.67 | NOTUM (0.61) | NOTUMTSHRMAPTHPGDALDH1A1 | |
| SCHEMBL23489040 | 0.66 | CYP2C9 (0.49) | L3MBTL1MAPTHPGDALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10364267-B2 | Deuterated bile acid derivatives as FXR/TGR5 agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2019-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10364267-B2 | Deuterated bile acid derivatives as FXR/TGR5 agonists and methods of use thereof | NR1H4, GPBAR1, SLC10A1 | NOTUM 804/4885GPR119 36/4885TSHR 133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.