Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 1/20 | 0.69 |
| ▸ | KRAS | P01116 | 1/20 | 0.69 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.39 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.38 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21198059 | 0.92 | HRAS (0.69) | HRASKRASPDCD1CD274CHEK2 | |
| SCHEMBL21198764 | 0.90 | HRAS (0.61) | HRASKRASAKR1C3AKR1C2STIM1 | |
| SCHEMBL30913763 | 0.90 | HRAS (0.61) | HRASKRASAKR1C3AKR1C2STIM1 | |
| SCHEMBL21198782 | 0.88 | HRAS (0.74) | HRASKRASPDCD1CD274KDM4E | |
| SCHEMBL30913802 | 0.88 | HRAS (0.74) | HRASKRASPDCD1CD274KDM4E | |
| SCHEMBL21207076 | 0.86 | HRAS (0.71) | HRASKRASPDCD1CD274 | |
| SCHEMBL30222612 | 0.86 | HRAS (0.74) | HRASKRASPDCD1CD274 | |
| SCHEMBL21207083 | 0.86 | HRAS (0.74) | HRASKRASPDCD1CD274 | |
| SCHEMBL21198599 | 0.85 | HRAS (0.79) | HRASKRASPDCD1CD274 | |
| SCHEMBL21207061 | 0.84 | HRAS (0.58) | HRASKRASAKR1C3AKR1C2PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12024506-B2 | Compounds | THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) | 2024-07-02 | — | — | US | disclosed |
| US-12024506-B2 | Compounds | THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) | 2024-07-02 | — | — | US | disclosed |
| US-20210009576-A1 | COMPOUNDS | THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) | 2021-01-14 | — | — | US | disclosed |
| WO-2019145718-A1 | COMPOUNDS | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2019-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210009576-A1 | COMPOUNDS | KRAS, NRAS, HRAS | HRAS 3/4885KRAS 1/4885HPGDS 595/4885 |
| US-12024506-B2 | Compounds | KRAS, NRAS, HRAS | HRAS 3/4885KRAS 1/4885HPGDS 595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.