Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 1/20 | 0.74 |
| ▸ | KRAS | P01116 | 1/20 | 0.74 |
| ▸ | CD274 | Q9NZQ7 | 8/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 6/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.36 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21198782 | 1.00 | HRAS (0.74) | HRASKRASCD274PDCD1NR1H4 | |
| SCHEMBL30222612 | 0.93 | HRAS (0.74) | HRASKRASCD274PDCD1PDCD1LG2 | |
| SCHEMBL21207083 | 0.93 | HRAS (0.74) | HRASKRASCD274PDCD1PDCD1LG2 | |
| SCHEMBL21207032 | 0.91 | HRAS (0.64) | HRASKRASCD274PDCD1PDE4B | |
| SCHEMBL21198599 | 0.89 | HRAS (0.79) | HRASKRASCD274PDCD1PDCD1LG2 | |
| SCHEMBL21207183 | 0.88 | HRAS (0.69) | HRASKRASCD274PDCD1KDM4E | |
| SCHEMBL21198397 | 0.88 | HRAS (0.80) | HRASKRASCD274PDCD1PDCD1LG2 | |
| SCHEMBL21207151 | 0.86 | HRAS (0.65) | HRASKRASMAPT | |
| SCHEMBL30913723 | 0.86 | HRAS (0.65) | HRASKRASMAPT | |
| SCHEMBL21198059 | 0.86 | HRAS (0.69) | HRASKRASCD274PDCD1CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12024506-B2 | Compounds | THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) | 2024-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12024506-B2 | Compounds | KRAS, NRAS, HRAS | HRAS 3/4885KRAS 1/4885CD274 3721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.