Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 20/20 | 0.65 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8245437 | 0.86 | CRBN (0.74) | CRBNDDB1BRD4IKZF3 | |
| SCHEMBL29913826 | 0.85 | CRBN (0.72) | CRBNDDB1BRD4IKZF3 | |
| SCHEMBL27362185 | 0.85 | CRBN (0.72) | CRBNDDB1BRD4IKZF3 | |
| SCHEMBL29913668 | 0.85 | CRBN (0.72) | CRBNDDB1BRD4IKZF3 | |
| SCHEMBL29913697 | 0.85 | CRBN (0.72) | CRBNDDB1BRD4IKZF3 | |
| SCHEMBL24083581 | 0.81 | CRBN (0.55) | CRBNDDB1BRD4IKZF3 | |
| SCHEMBL20811949 | 0.81 | CRBN (0.83) | CRBNDDB1BRD4IKZF3 | |
| SCHEMBL17884726 | 0.81 | CRBN (0.54) | CRBNDDB1BRD4IKZF3 | |
| SCHEMBL8277941 | 0.81 | CRBN (0.69) | CRBNDDB1BRD4IKZF3 | |
| Trifluoroacetic Acid SCHEMBL30635277 | 0.79 | CRBN (0.63) | CRBNDDB1BRD4IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019148055-A9 | IMIDE-BASED MODULATORS OF PROTEOLYSIS AND METHODS OF USE | YALE UNIVERSITY (US) | 2019-09-26 | — | — | WO | disclosed |
| WO-2019148055-A1 | IMIDE-BASED MODULATORS OF PROTEOLYSIS AND METHODS OF USE | YALE UNIVERSITY (US) | 2019-08-01 | — | — | WO | disclosed |