Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 20/20 | 0.72 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.67 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.56 |
| ▸ | BRD4 | O60885 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29913826 | 1.00 | CRBN (0.72) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL29913668 | 1.00 | CRBN (0.72) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL27362185 | 1.00 | CRBN (0.72) | CRBNDDB1IKZF3BRD4 | |
| Trifluoroacetic Acid SCHEMBL30635277 | 0.93 | CRBN (0.63) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL21207985 | 0.85 | CRBN (0.65) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL4778728 | 0.85 | CRBN (0.74) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL20811963 | 0.85 | CRBN (0.74) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL20811949 | 0.85 | CRBN (0.83) | CRBNDDB1IKZF3BRD4 | |
| SCHEMBL31507408 | 0.84 | CRBN (0.78) | CRBNDDB1IKZF3 | |
| SCHEMBL23267776 | 0.84 | CRBN (0.72) | CRBNDDB1IKZF3BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120152967-A | Bifunctional compounds containing 2, 5-substituted pyrimidine derivatives for degradation of cyclin-dependent kinase 2 via the ubiquitin proteasome pathway | 霖康疗法公司 | 2025-06-13 | — | — | CN | claimed |
| CN-120004863-A | ALK protein degradation agent and application thereof in resisting tumor | 江苏天士力帝益药业有限公司 | 2025-05-16 | — | — | CN | claimed |
| CN-120118067-A | Estrogen receptor modulators and uses thereof | 江苏威凯尔医药科技股份有限公司 | 2025-06-10 | — | — | CN | disclosed |
| CN-120004863-A | ALK protein degradation agent and application thereof in resisting tumor | 江苏天士力帝益药业有限公司 | 2025-05-16 | — | — | CN | disclosed |
| CN-119019369-A | Bifunctional molecules comprising an E3 ubiquitin ligase binding moiety linked to a BCL6 targeting moiety | 阿尔维纳斯运营股份有限公司 | 2024-11-26 | — | — | CN | disclosed |
| CN-118638043-A | Compounds and methods for targeted degradation of androgen receptor | 阿尔维纳斯运营股份有限公司 | 2024-09-13 | — | — | CN | disclosed |
| CN-115397821-B | Bifunctional molecules comprising an E3 ubiquitin ligase binding moiety linked to a BCL6 targeting moiety | 阿尔维纳斯运营股份有限公司 | 2024-09-03 | — | — | CN | disclosed |
| CN-118234726-A | Chimeric compound for androgen receptor protein targeted degradation, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-118059104-A | Compounds and methods for targeted degradation of androgen receptor | 阿尔维纳斯运营股份有限公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-116888108-B | Novel EGFR degradation agent | 上海齐鲁制药研究中心有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-115175901-B | Compounds and methods for targeted degradation of androgen receptor | 阿尔维纳斯运营股份有限公司 | 2024-03-22 | — | — | CN | disclosed |
| CN-116888108-A | Novel EGFR degradation agent | 上海齐鲁制药研究中心有限公司 | 2023-10-13 | — | — | CN | disclosed |
| EP-4077309-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas Operations, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115175901-A | Compounds and methods for targeted degradation of androgen receptor | 阿尔维纳斯运营股份有限公司 | 2022-10-11 | — | — | CN | disclosed |