Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.58 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.58 |
| ▸ | CDK7 | P50613 | 1/20 | 0.58 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.58 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.58 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.58 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.58 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17132891 | 0.77 | MAP4K4 (0.63) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL24798104 | 0.77 | MAP4K4 (0.63) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL25331825 | 0.76 | MAP4K4 (0.58) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL7827526 | 0.73 | MAP4K4 (1.00) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL4127301 | 0.73 | HDAC2 (0.48) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL17131641 | 0.72 | MAP4K4 (0.58) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL25518955 | 0.72 | MAP4K4 (0.58) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL29940831 | 0.71 | APOBEC3A (0.49) | — | |
| SCHEMBL29659576 | 0.70 | MAP4K4 (0.71) | MAP4K4ABL1MAPK8CSNK1A1CDK7 | |
| SCHEMBL14831925 | 0.69 | DRD2 (0.44) | MAP4K4ABL1MAPK8CSNK1A1CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |