Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.46 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.39 |
| ▸ | CYP21A2 | P08686 | 4/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | SIK1 | P57059 | 1/20 | 0.38 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.38 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | EIF4E | P06730 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30027855 | 1.00 | PIK3CD (0.46) | PIK3CDEIF2AK4WNT3AACVR1TGFBR1 | |
| SCHEMBL21192956 | 0.88 | PIK3CD (0.47) | PIK3CDEIF2AK4ACVR1FYN | |
| SCHEMBL21209398 | 0.82 | EIF2AK4 (0.51) | PIK3CDEIF2AK4WNT3AACVR1FYN | |
| SCHEMBL21210758 | 0.82 | EIF2AK4 (0.46) | EIF2AK4WNT3AACVR1SIK1SIK2 | |
| SCHEMBL30027579 | 0.79 | EIF2AK4 (0.48) | PIK3CDEIF2AK4WNT3AACVR1 | |
| SCHEMBL21210900 | 0.79 | EIF2AK4 (0.48) | PIK3CDEIF2AK4WNT3AACVR1 | |
| SCHEMBL30027028 | 0.78 | EIF2AK4 (0.46) | EIF2AK4EIF4EMKNK1MKNK2ABCG2 | |
| SCHEMBL21209406 | 0.78 | EIF2AK4 (0.46) | EIF2AK4EIF4EMKNK1MKNK2ABCG2 | |
| SCHEMBL21193371 | 0.76 | EIF2AK4 (0.60) | EIF2AK4TGFBR1EIF4EMKNK1MKNK2 | |
| SCHEMBL30803914 | 0.76 | EIF2AK4 (0.60) | EIF2AK4TGFBR1EIF4EMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340577-A1 | GCN2 INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED | 2022-10-27 | — | — | US | disclosed |
| US-10988477-B2 | GCN2 inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2021-04-27 | — | — | US | disclosed |
| WO-2019148132-A1 | GCN2 INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-08-01 | — | — | WO | disclosed |
| US-20190233425-A1 | GCN2 INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220340577-A1 | GCN2 INHIBITORS AND USES THEREOF | EIF2AK4, GCN1, GCGR | PIK3CD 2323/4885EIF2AK4 1/4885WNT3A 3187/4885 |
| US-10988477-B2 | GCN2 inhibitors and uses thereof | EIF2AK4, GCN1, EIF2AK1 | PIK3CD 1141/4885EIF2AK4 1/4885WNT3A 3219/4885 |
| US-20190233425-A1 | GCN2 INHIBITORS AND USES THEREOF | EIF2AK4, GCN1, GCGR | PIK3CD 2323/4885EIF2AK4 1/4885WNT3A 3187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.