⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31426 | 0.73 | — | — | |
| SCHEMBL23133061 | 0.73 | — | — | |
| SCHEMBL242031 | 0.72 | — | — | |
| SCHEMBL11513414 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL2748684 | 0.71 | — | — | |
| SCHEMBL42725 | 0.71 | — | — | |
| SCHEMBL24845999 | 0.71 | PPARA (0.56) | — | |
| SCHEMBL3871336 | 0.69 | — | — | |
| SCHEMBL22502867 | 0.69 | — | — | |
| SCHEMBL2882816 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023225001-A1 | NAPHTHYRIDINE BASED ENPP1 MODULATORS AND USES THEREOF | Vir Biotechnology, Inc. (US) | 2023-11-23 | — | — | WO | disclosed |
| WO-2023009554-A1 | METHODS TO REDUCE ADVERSE EFFECTS OF GENE OR BIOLOGICS THERAPY | AVILAR THERAPEUTICS, INC. (US) | 2023-02-02 | — | — | WO | disclosed |
| US-20210040083-A1 | GCN2 INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2021-02-11 | — | — | US | disclosed |
| US-10793563-B2 | GCN2 inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2020-10-06 | — | — | US | disclosed |
| WO-2019148132-A1 | GCN2 INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-08-01 | — | — | WO | disclosed |
| US-20190233411-A1 | GCN2 INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-08-01 | — | — | US | disclosed |